Blar i Brage NIH på forfatter "Seaborne, Robert A."
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The comparative methylome and transcriptome after change of direction compared to straight line running exercise in human skeletal muscle
Massar, Mohd Firdaus; Turner, Daniel C.; Gorski, Piotr Patryk; Seaborne, Robert A.; Strauss, Juliette A.; Shepherd, Sam O.; Cocks, Matt; Zierath, Juleen R.; Drust, Barry; Pillon, Nicolas J.; Hulton, Andrew T.; Sharples, Adam P. (Peer reviewed; Journal article, 2021)The methylome and transcriptome signatures following exercise that are physiologically and metabolically relevant to sporting contexts such as team sports or health prescription scenarios (e.g., high intensity interval ... -
DNA methylation across the genome in aged human skeletal muscle tissue and muscle‑derived cells: The role of HOX genes and physical activity
Turner, Daniel C.; Gorski, Piotr Patryk; Massar, Mohd Firdaus; Seaborne, Robert A.; Baumert, Phillipp; Brown, Alexander D.; Erskine, Robert M.; Dos-Remedios, Ian; Voisin, Sarah; Eynon, Nir; Borisov, Oleg; Larin, Andrey; Semenova, Ekaterina A.; Popov, Daniil; Drust, Barry; Owens, Daniel J.; Ahmetov, Ildus I.; Sharples, Adam; Kitchen, Mark O.; Sultanov, R. I.; Generozov, Edward V.; Stewart, Claire E. (Peer reviewed; Journal article, 2020)Skeletal muscle tissue demonstrates global hypermethylation with age. However, methylome changes across the time-course of differentiation in aged human muscle derived cells, and larger coverage arrays in aged muscle tissue ... -
Knockdown of the E3 Ubiquitin ligase UBR5 and its role in skeletal muscle anabolism
Hughes, David C.; Turner, Daniel C.; Baehr, Leslie M.; Seaborne, Robert A.; Viggars, Mark; Jarvis, Jonathan C.; Gorski, Piotr Patryk; Stewart, Claire E.; Owens, Daniel J.; Bodine, Sue C.; Sharples, Adam (Peer reviewed; Journal article, 2020)UBR5 is an E3-ubiquitin-ligase positively associated with anabolism, hypertrophy and recovery from atrophy in skeletal muscle. The precise mechanisms underpinning UBR5's role in the regulation of skeletal muscle mass remains ... -
Mechanical loading of bioengineered skeletal muscle in vitro recapitulates gene expression signatures of resistance exercise in vivo
Turner, Daniel C.; Gorski, Piotr Patryk; Seaborne, Robert A.; Viggars, Mark; Murphy, Mark; Jarvis, Jonathan C.; Martin, Neil R. W.; Stewart, Claire E.; Sharples, Adam P. (Peer reviewed; Journal article, 2021)Understanding the role of mechanical loading and exercise in skeletal muscle (SkM) is paramount for delineating the molecular mechanisms that govern changes in muscle mass. However, it is unknown whether loading of ... -
Resistance training rejuvenates the mitochondrial methylome in aged human skeletal muscle
Ruple, Bradley A; Godwin, Joshua S.; Mesquita, Paulo H. C; Osburn, Shelby C; Vann, Christopher G; Lamb, Donald A; Sexton, Casey L; Candow, Darren G; Forbes, Scott C; Frugé, Andrew D.; Kavazis, Andreas N; Young, Kaelin C; Seaborne, Robert A.; Sharples, Adam; Roberts, Michael D (Peer reviewed; Journal article, 2021)Resistance training (RT) dynamically alters the skeletal muscle nuclear DNA methylome. However, no study has examined if RT affects the mitochondrial DNA (mtDNA) methylome. Herein, ten older, Caucasian untrained males (65 ...